HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 8-Cyclopropyl-4,4-dimethyl-6-ethynyl-1-tetralone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Cyclopropyl-4,4-dimethyl-6-(trimethylsilanyl)ethynyl-1-tetralone | HCID 21107242 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 8-Cyclopropyl-4,4-dimethyl-6-ethynyl-1-tetralone | HCID 21107241 | — |
Reaction Steps
Following General Procedure F and using 8-cyclopropyl-4,4-dimethyl-6-(trimethylsilanyl)ethynyl-1-tetralone (Intermediate 159, 1.05 g, 3.38 mmol), methanol (20 mL) and potassium carbonate (1 g, 14.5 mmol) followed by flash column chromatography using 7% ethyl acetate in hexane as the eluent, the title compound was obtained (0.57 g, 80%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468391B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-cb5f8d7085fd4f45936b1fcb21f35424 |
| Source note | uspto-grants-2008_12 |