反应详情

温度

0 °C

2-Methylaziridine (3.6 ml, 51 mmol) was added to a 10% aqueous KOH solution (30 ml) and cooled in an ice bath for 30 min. To this solution p-toluenesulfonyl chloride (9.9 g, 52 mmol) was added rapidly while maintaining the temperature below 4° C. The resulting mixture was stirred for 30 min at 0° C., then stirred at room temperature overnight. The white precipitate was washed multiple times with cold water and dried under vacuum. The washed product was dissolved in hot petroleum ether and allowed to crystallize at 0° C., yielding colorless crystals (6.3 g, 57% yield).

1. temperaturecooled in an ice bath for 30 min
2. temperaturewhile maintaining the temperature below 4° C
3. stirringstirred at room temperature overnight
4. washThe white precipitate was washed multiple times with cold water
5. customdried under vacuum
6. dissolutionThe washed product was dissolved in hot petroleum ether
7. customto crystallize at 0° C.