Benzylamine → HCID 57431197, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 1-bromo-2,3-bis(bromomethyl)-4-methoxybenzene (prepared as described in J. Org. Chem. 1992, 57, 6374, from commercially available 1-bromo-4-methoxy-2,3-dimethylbenzene) in CH3CN (0.1 M) were added 2.5 eq of KHCO3 and the mixture heated at 60° C. Then 1 eq. of benzylamine in CH3CN (0.9 M) was added within 15 minutes and the mixture was heated to reflux for 2 h. The reaction mixture was allowed to cool, filtered over celite and concentrated in vacuo. The crude material was purified by flash chromatography on silica gel (5% EtOAc in petroleum ether, then 10%) to afford the title compound (55%). 1H NMR (300 MHz, CDCl3, ppm) δ 3.77 (s, 3H), 3.92 (s, 2H), 3.98 (s, 2H), 4.01 (s, 2H), 6.60 (d, J 8.6, 1H), and 7.22-7.46 (m, 6H). MS (ES+) m/z 318, 320 (M+H)+.

Provenance & Evidence