HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377648Generated: October 26, 2026
1,3-Diethyl 2-oxopropanedioate → Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate
https://huagongshe.com/reaction/2377648
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Diethyl 2-oxopropanedioate | HCID 69105 | — |
| Reactant | 1-(2-(Ethylamino)pyrimidin-4-yl)ethanone | HCID 68452125 | — |
| Product | Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate | HCID 68452836 | — |
Reaction Steps
A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase: methylene chloride:methanol=98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07470689B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-8af1cb5a3b074eabadb65b118d9aae2e |
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| Source note | uspto-grants-2008_12 |
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