1-(2-Fluorophenyl)piperazine → HCID 10451194, compound

HRID 2377670Notes

Reaction equation

HRID 2377670 reaction equation
Br[CH2:2][C:3]1[C:7]2[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:6]=2[S:5][CH:4]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]2[S:5][CH:4]=[C:3]([CH2:2][N:23]3[CH2:22][CH2:21][N:20]([C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[F:13])[CH2:25][CH2:24]3)[C:7]=2[CH:8]=1

Participants

3

Reactant 2

HCID 705291-(2-Fluorophenyl)piperazineHCID 27798573-(Bromomethyl)-5-chloro-1-benzothiophene

Product 1

HCID 10451194HCID 10451194, compound

Procedure

3-(Bromomethyl)-5-chloro-1-benzothiophene and 1-(2-fluorophenyl)piperazine were processed as described in Example 2 to provide the title compound. 1H NMR (d6-DMSO, 300 MHz) δ 2.65 (m, 2H), 3.02 (m, 6H), 3.78 (s, 2H), 6.92-7.10 (m, 4H), 7.40 (dd, 1H, J=8.7, 1.5), 7.67 (s, 1H), 7.78 (d, 1H, J=8.7 Hz), 8.06 (d, 1H, J=1.5 Hz). MS (DCI/NH3) m/z 361.0 (M+H)+. Anal. Calcd for C19H18N2SClF: C, 63.24;H, 5.03; N, 7.76. Found: C, 63.17;H, 4.90; N, 7.67.

Sources & evidence

ORD record
ord-d692069f047347f58432a46e79755935
Source dataset
uspto-grants-2008_12
Patent number
US07470691B2

Reaction notes

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