1-(2-Pyrimidinyl)piperazine → 2-{4-[(5-Chloro-1-benzothien-3-yl)methyl]-1-piperazinyl}pyrimidine

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Reaction Steps

3-(Bromomethyl)-5-chloro-1-benzothiophene and 2-(1-piperazinyl)pyrimidine were processed as described in Example 2 to provide the title compound. 1H NMR (CDCl3, 300 MHz) δ (2.62-2.9 (m, 4H), 3.75 (m, 6H), 6.6 (m, 1H), 7.38 (m, 2H), 7.85 (m, 2H), 8.31 (M, 2H). MS (DCI/NH3) m/z 345.0 (M+H)+; Anal. Calcd for C17H17ClN4S: C, 53.04;H, 4.74; N, 14.55. Found: C, 52.79;H, 4.41; N, 14.55.

Provenance & Evidence