Formaldehyde → HCID 11779225, compound

HRID 2377684Notes

Reaction equation

HRID 2377684 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[N:10]1([C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:22]([O-])(=O)C.[Na+].C=O>>[N:21]1[CH:20]=[CH:19][CH:18]=[N:17][C:16]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:22][C:2]2[NH:1][C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:4]3[CH:3]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 887471-(2-Pyrimidinyl)piperazineHCID 517045Sodium Acetate

Product 1

HCID 11779225HCID 11779225, compound

Procedure

1H-pyrrolo[2,3-b]pyridine (47 mg, 0.40 mmol), 2-(1-piperazinyl)pyrimidine (65 mg, 0.48 mmol), sodium acetate (72 mg, 0.53 mmol), and formaldehyde (0.48 mmol) were processed as described in Example 18 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 2.42 (m, 4H) 3.68 (m, 4H) 4.05 (s, 2H) 5.59 (s, 1H) 6.60 (m, 1H) 7.08 (m, 2H) 7.37 (m, 2H 8.07 (m, 2H). (ESI) m/z 295 (M+H)+.

Sources & evidence

ORD record
ord-edf955700ab74efdadecc9ef59583738
Source dataset
uspto-grants-2008_12
Patent number
US07470691B2

Reaction notes

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