1-(2-Methoxyphenyl)piperazine → HCID 10092802, compound

HRID 2377692Notes

Reaction equation

HRID 2377692 reaction equation
CS(O[CH2:6][C:7]1[S:15][C:14]2[C:9](=[N:10][CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:13]=2)[CH:8]=1)(=O)=O.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:6][C:7]2[S:15][C:14]3[C:9](=[N:10][CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:13]=3)[CH:8]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 22065976HCID 22065976, compound

Product 1

HCID 10092802HCID 10092802, compound

Procedure

The solution from Example 25C (2 mL) and 1-(2-methoxyphenyl)piperazine (192 mg) were processed as described in Example 25D to provide the title compound. 1H NMR (CDCl3, 300 MHz) δ 3.11 (4H, t, J=4.8 Hz), 3.45 (4H, J=4.8 Hz), 4.19 (s, 3H), 4.30 (s, 2H), 6.90 (4H, m), 7.80 (1H, s), 8.63 (1H, m), 9.20 (1H, m). MS (DCI/NH3) m/z 408.2 (M+H)+. Anal. Calcd for C20H20N3F3OS: C, 58.96;H, 4.95; N, 10.31. Found: C, 58.98;H, 4.95; N, 10.53.

Sources & evidence

ORD record
ord-852be5f951ec49e8952456d6212e0287
Source dataset
uspto-grants-2008_12
Patent number
US07470691B2

Reaction notes

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