N-(2-Cyanophenyl)piperazine → HCID 10092500, compound

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Reaction Steps

The solution from Example 25C (2 mL) and 2-(1-piperazinyl)benzonitrile (187 mg) were processed as described in Example 25D to provide the title compound. 1H NMR (CDCl3, 300 MHz) δ 2.81 (4H, t, J=4.8 Hz), 3.29 (4H, J=4.8 Hz), 4.00 (s, 2H), 7.03 (2H, m), 7.50 (2H, m), 7.59 (dd, 1H, J=7.5, 1.5 Hz), 8.39 (1H, m), 8.86 (1H, m). MS (DCI/NH3)m-z 403.1 (M+H)+. Anal. Calcd for C20H17N4F3S: C, 59.69;H, 4.26; N, 13.92. Found: C, 59.53;H, 4.12; N, 14.22.

Provenance & Evidence