(S)-5-(4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine → 2(S)-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxymethyl]-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

HRID 237771Notes

Reaction equation

HRID 237771 reaction equation
[CH3:1][C:2]([C:9]1[CH:22]=[CH:21][C:12]([O:13][CH2:14][C@H:15]2[O:19][C:18]([NH2:20])=[N:17][CH2:16]2)=[CH:11][CH:10]=1)([CH3:8])[CH2:3][C:4]([CH3:7])([CH3:6])[CH3:5]>C(Cl)(Cl)Cl>[CH3:8][C:2]([C:9]1[CH:22]=[CH:21][C:12]([O:13][CH2:14][C@H:15]2[O:19][C:18]3=[N:20][C:12](=[O:13])[CH:11]=[CH:10][N:17]3[CH2:16]2)=[CH:11][CH:10]=1)([CH3:1])[CH2:3][C:4]([CH3:5])([CH3:6])[CH3:7]

Participants

3

Reactant 1

HCID 68529278(S)-5-(4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

Product 1

HCID 250739142(S)-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxymethyl]-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from (S)-5-(4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine employing the procedures as set forth in Step 3 of Example 1. [α]D25 −43.52 (c 0.551, CHCl3).

Sources & evidence

ORD record
ord-b5e1c2db415243659528100ae9891a56
Source dataset
uspto-grants-2014_02
Patent number
US08642603B2

Reaction notes

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