2-Bromobenzyl bromide → HCID 11186192, compound

HRID 2377756Notes

Reaction equation

HRID 2377756 reaction equation
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([F:9])=[CH:4][N:3]=1.[Br:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13]Br>>[Br:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][N:7]1[C:6](=[O:8])[C:5]([F:9])=[CH:4][N:3]=[C:2]1[Cl:1]

Participants

3

Reactant 2

HCID 769652-Bromobenzyl bromideHCID 2553942-Chloro-5-fluoropyrimidin-4(3H)-one

Product 1

HCID 11186192HCID 11186192, compoundYield 11%

Procedure

The title compound was prepared in 11% yield from 2-chloro-5-fluoro-3H-pyrimidin-4-one and 2-bromobenzyl bromide according to the procedure for Example 1B. 1H NMR (400 MHz, CDCl3): δ 7.82 (d, 1H, J=1.2 Hz), 7.62 (dd, 1H, J=7.6, 1.2 Hz), 7.17-7.30 (m, 2H), 6.78 (d, 1H, J=7.6 Hz), 5.52 (s, 2H). MS (ES) [m+H] calc'd for C11H7N2OFClBr, 317, 319; found 317, 319.

Sources & evidence

ORD record
ord-1bede3cd848246f2bb87e0ea34078794
Source dataset
uspto-grants-2008_12
Patent number
US07470700B2

Reaction notes

Loading…