Methanol → 2-(4-Fluorophenylamino)but-2-enedioic Acid Dimethyl Ester

Participants

Reaction Conditions

Reaction Steps

50 ml (0.51 M) of 4-fluoroaniline (at 98%) are introduced into 500 ml of anhydrous methanol, followed by dropwise addition of 70.5 ml (0.56 M) of methyl acetylenedicarboxylate (at 98%). The reaction mixture is heated at 55° C. with stirring for 3 hours, and then evaporated under reduced pressure. The residue is purified by evolution through silica.

Provenance & Evidence