HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377825Generated: November 1, 2026
Water → 5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile
https://huagongshe.com/reaction/2377825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 5-Fluoro-2-nitrobenzonitrile | HCID 3756467 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile | HCID 16102059 | — |
Reaction Steps
5-Fluoro-2-nitrobenzenecarbonitrile (1.02 equivalents) and N-methylpiperazine (1.0 equivalents) were dissolved in NMP. Triethylamine (2.1 equivalents) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rt 1.46 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07470709B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-d17b1ad34b214069bad551d0d9ab613e |
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| Source note | uspto-grants-2008_12 |
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