HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 12988784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Morpholinoethanol | HCID 61163 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | 4-Amino-3-Nitrophenol | HCID 3758882 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12988784 | HCID 12988784 | — |
Reaction Steps
Diisopropyl azodicarboxylate (1.1 equivalents) was added dropwise to a stirred solution of 4-amino-3-nitrophenol (1.0 equivalent), triphenylphosphine (1.1 equivalents), and N-(2-hydroxyethyl)morpholine (1.0 equivalent), in THF at 0° C. The mixture was allowed to warm to room temperature and left to stir for 18 hours. The solvent was evaporated and the product was purified by silica gel chromatography (98:2 CH2Cl2:MeOH) to yield a dark reddish-brown oil. LC/MS m/z 268.0 (MH+), Rt 1.01 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470709B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-a1de213e9dbc4f35802b5945b4bea068 |
| Source note | uspto-grants-2008_12 |