HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377847Generated: October 31, 2026
O-Phenylenediamine → 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthyridin-2(1H)-one
https://huagongshe.com/reaction/2377847
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid | HCID 12988781 | — |
| Product | 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthyridin-2(1H)-one | HCID 135410286 | — |
Reaction Steps
3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid (1.1 equivalents) was combined with 1,2-phenylenediamine (1.0 equivalent) and heated at 150° C. for 3 hours. The crude product was purified by reversed-phase HPLC (DMSO/5% TFA). LC/MS m/z 279.3 (MH+), Rt 1.73 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07470709B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-bdf9ed4482af433086f17d0126d6ad78 |
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| Source note | uspto-grants-2008_12 |
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