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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377848Generated: October 27, 2026

3,4-Diaminotoluene → 4-Hydroxy-3-(6-methyl-1H-benzoimidazol-2-yl)-1H-[1,7]naphthyridin-2-one

https://huagongshe.com/reaction/2377848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DiaminotolueneHCID 10332—
Reactant3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acidHCID 12988781—
Product4-Hydroxy-3-(6-methyl-1H-benzoimidazol-2-yl)-1H-[1,7]naphthyridin-2-oneHCID 135518153—

Reaction Steps

The title compound was synthesized as described in Example 50 using 3-[2-(methoxycarbonyl)acetylamino]-pyridine-4-carboxylic acid and 4-methyl-1,2-phenylenediamine. The crude product was purified by reversed-phase HPLC (DMSO/5% TFA). LC/MS m/z 293.3 (MH+), Rt 1.99 minutes.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07470709B2
Source datasetuspto-grants-2008_12
ORD IDord-5f5eb08ea64e4171a92955412b8c7a7a
Source noteuspto-grants-2008_12