HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377853Generated: October 31, 2026
Methylamine → 1-(4-Benzylmorpholin-2-yl)-N-methylmethanamine
https://huagongshe.com/reaction/2377853
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-Benzyl-2-(chloromethyl)morpholine | HCID 2801562 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Benzylmorpholin-2-yl)-N-methylmethanamine | HCID 51358399 | — |
Reaction Steps
Commercially available 2-chloromethyl-4-benzyl morpholine was dissolved in an 8 M solution of NH2Me in EtOH and heated in a glass pressure vessel at 110° C. overnight. The solvent was removed in vacuo, and the compound was used in the next step without further purification. LC/MS m/z: 221.2 (MH+), Rt 0.55 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07470709B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-fcbbde9f0b62443a9c73e4cc510aed72 |
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| Source note | uspto-grants-2008_12 |
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