Epichlorohydrin → 5-Oxiranylmethoxy-1H-indole

HRID 237792Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH2:11]([CH:13]1[O:15][CH2:14]1)Cl>>[O:15]1[CH2:14][CH:13]1[CH2:11][O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2

Participants

Reactant 2

HCID 7835Epichlorohydrin

HCID 160545-Hydroxyindole

Product 1

HCID 98556905-Oxiranylmethoxy-1H-indole

Procedure

The title compound was prepared from 5-hydroxyindole and epichlorohydrin employing the procedures as set forth in Step 1 of Example 2.

Sources & evidence

ORD record: ord-c3db999b430a49b78173ece61803ea5a
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642603B2

Reaction notes

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