4-Iodo-2-methoxy-3-(5-phenyl-1H-imidazol-2-yl)-pyridine → 4-Ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol

Participants

Reaction Steps

4-Iodo-2-methoxy-3-(5-phenyl-1H-imidazol-2-yl)-pyridine and 2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol: Isonitrosoacetophenone (0.030 g, 0.114 mmol) was reacted as described for the synthesis of 4-ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol and gave 4-iodo-2-methoxy-3-(5-phenyl-1H-imidazol-2-yl)-pyridine (0.008 g, 19%) and 2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol (0.007 g, 16%). 4-Iodo-2-methoxy-3-(5-phenyl-1H-imidazol-2-yl)-pyridine: LCMS (+ESI, M+H+) m/z 378; 1H NMR (400 MHz, DMSO-d6) δ (ppm): 3.83 (3H, s), 7.17-7.97 (8H, m), 12.29 and 12.60 (1H, 2 br s). 2-(4-Iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol: : LCMS (+ESI, M+H+) m/z 378; 1H NMR (400 MHz, DMSO-d6) δ (ppm): 3.82 and 3.92 (3H, 2 d), 7.19-8.05 (8H, m), 11.68 and 12.70 (1H, 2s).

Provenance & Evidence