HCID 87770298, compound → HCID 23146388, compound

Participants

Reaction Steps

To a solution of (RS)-1-(2-3-bromo-benzofuran-2-ylmethyl-piperidin-1-yl)-2,2,2-trifluoro-ethanone, D41 (840 mg, 2.1 mmol) in N-methylpyrrolidinone (15 ml) was added copper(I)cyanide (387 mg, 4.2 mmol) and the mixture refluxed for 4.5 h. The reaction mixture was cooled sand diluted with water (100 ml), 0.880 ammonia (3 ml) and ethyl acetate (3×). The combined extracts were dried (Na2SO4) and the solvent removed in vacuo. The residual oil was redissolved in ethyl acetate (75 ml) and washed with water (4×), brine, dried (Na2SO4) and the solvent removed in vacuo. Chromatography (silica gel) afforded the title compound as a solid.

Provenance & Evidence