2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146369, compound

HRID 2378029Notes

Reaction equation

HRID 2378029 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:19]=[C:20]([Cl:35])[C:21]2[O:25][C:24]([CH2:26][CH:27]3[NH:32][CH2:31][CH2:30][N:29]([CH3:33])[CH2:28]3)=[CH:23][C:22]=2[CH:34]=1>>[Cl:17][C:18]1[CH:19]=[C:20]([Cl:35])[C:21]2[O:25][C:24]([CH2:26][CH:27]3[CH2:28][N:29]([CH3:33])[CH2:30][CH2:31][N:32]3[C:14]([C:9]3[N:10]=[C:11]([CH3:13])[S:12][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[O:15])=[CH:23][C:22]=2[CH:34]=1

Participants

3

Reactant 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chlorideHCID 23146315HCID 23146315, compound

Product 1

HCID 23146369HCID 23146369, compound

Procedure

The title compound (80 mg) was prepared from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl chloride (498 mg) and (RS)-3-(5,7-dichloro-benzofuran-2-ylmethyl)-1-methyl-piperazine, D65 (530 mg) by a procedure similar to that described for Example 1.

Sources & evidence

ORD record
ord-369f64ccd3034a42836c7e91a058d109
Source dataset
uspto-grants-2008_12
Patent number
US07470710B2

Reaction notes

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