Acid Blue 3 → HCID 23146357, compound

HRID 2378031Notes

Reaction equation

Br[C:2]1[C:7]2[CH:8]=[C:9]([CH2:11][CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[C:18]([C:20]3[N:21]=[C:22]([CH3:32])[S:23][C:24]=3[C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)=[O:19])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C[CH2:34][N:35](C1C=CC(C(C2C(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C(O)C=2)=C2C=CC(=[N+](CC)CC)C=C2)=CC=1)CC.CCN(C1C=CC(C(C2C(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C(O)C=2)=C2C=CC(=[N+](CC)CC)C=C2)=CC=1)CC.[Ca+2].[Cu]C#N>>[C:34]([C:2]1[C:7]2[CH:8]=[C:9]([CH2:11][CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[C:18]([C:20]3[N:21]=[C:22]([CH3:32])[S:23][C:24]=3[C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)=[O:19])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1)#[N:35]

Participants

Reactant 3

HCID 77073Acid Blue 3

HCID 23146248HCID 23146248, compound

HCID 178418546HCID 178418546, compound

Product 1

HCID 23146357HCID 23146357, compound

Procedure

The title compound (80 mg) was prepared from (RS)-1-[2-(4-bromo-benzofuran-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone, E131 (400 mg) and copper(I)cyanide according to a procedure similar to that described for Example 67.

Sources & evidence

ORD record: ord-2720891e718f4b9b91c23d4a0992f215
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07470710B2

Reaction notes

Loading…