4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid → HCID 23146353, compound

HRID 2378032Notes

Reaction equation

HRID 2378032 reaction equation
[F:1][C:2]1[C:7]2[CH:8]=[C:9]([CH2:11][CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][NH:13]3)[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[C:26]([C:31](O)=[O:32])=[N:27][N:28]([CH3:30])[CH:29]=2)=[CH:21][CH:20]=1>>[F:1][C:2]1[C:7]2[CH:8]=[C:9]([CH2:11][CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[C:31]([C:26]3[C:25]([C:22]4[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=4)=[CH:29][N:28]([CH3:30])[N:27]=3)=[O:32])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 197686484-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acidHCID 23146340HCID 23146340, compound

Product 1

HCID 23146353HCID 23146353, compound

Procedure

The title compound (45 mg) was prepared from (RS)-2-(4-fluoro-benzofuran-2-ylmethyl)-piperidine, D76 (157 mg) and 4-(4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (160 mg) according to a procedure similar to that described for Example 4.

Sources & evidence

ORD record
ord-206b63d201cf4ef0b32e7a511bcbfbb8
Source dataset
uspto-grants-2008_12
Patent number
US07470710B2

Reaction notes

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