2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146291, compound

HRID 2378033Notes

Reaction equation

HRID 2378033 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[Cl:17][C:18]1[C:23]2[CH:24]=[C:25]([CH2:27][CH:28]3[NH:33][CH2:32][CH2:31][N:30]([CH3:34])[CH2:29]3)[O:26][C:22]=2[CH:21]=[C:20]([Cl:35])[CH:19]=1>>[Cl:17][C:18]1[C:23]2[CH:24]=[C:25]([CH2:27][CH:28]3[CH2:29][N:30]([CH3:34])[CH2:31][CH2:32][N:33]3[C:14]([C:9]3[N:10]=[C:11]([CH3:13])[S:12][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[O:15])[O:26][C:22]=2[CH:21]=[C:20]([Cl:35])[CH:19]=1

Participants

3

Reactant 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chlorideHCID 23146336HCID 23146336, compound

Product 1

HCID 23146291HCID 23146291, compound

Procedure

The title compound (107 mg) was prepared from 5-(4-fluoro-phenyl)2-methyl-thiazole-4-carbonyl chloride (241 mg) and 3-(4,6-dichloro-benzofuran-2-ylmethyl)-1-methyl-piperazine, D78 (263 mg) by a procedure similar to that described for Example 1.

Sources & evidence

ORD record
ord-5395263bca7548f78f368861eba81455
Source dataset
uspto-grants-2008_12
Patent number
US07470710B2

Reaction notes

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