5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → (RS)-1-(2-Benzo[b]thiophen-2-ylmethyl-piperidin-1-yl)-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone

HRID 2378034Notes

Reaction equation

HRID 2378034 reaction equation
[S:1]1[C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)=[CH:4][C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[S:28][C:27]([CH3:29])=[N:26][C:25]=2[C:30](O)=[O:31])=[CH:20][CH:19]=1>>[S:1]1[C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][N:8]2[C:30]([C:25]2[N:26]=[C:27]([CH3:29])[S:28][C:24]=2[C:21]2[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=2)=[O:31])=[CH:4][C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2

Participants

3

Reactant 2

HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 23146368HCID 23146368, compound

Product 1

HCID 23146275(RS)-1-(2-Benzo[b]thiophen-2-ylmethyl-piperidin-1-yl)-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanoneYield 15.5%

Procedure

The title compound (40 mg) was prepared from 2-benzo[b]thiophen-2-ylmethyl-piperidine D83(133 mg) and 5-(4-fluoro-phenyl)2-methyl-thiazol-4-carboxylic acid (136 mg) according to a procedure similar to that described for Example 4.

Sources & evidence

ORD record
ord-5c2a7fe556c34efcbf3b31ae41861013
Source dataset
uspto-grants-2008_12
Patent number
US07470710B2

Reaction notes

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