4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid → HCID 23146244, compound

HRID 2378035Notes

Reaction equation

HRID 2378035 reaction equation
[S:1]1[C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)=[CH:4][C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:25]([C:30](O)=[O:31])=[N:26][N:27]([CH3:29])[CH:28]=2)=[CH:20][CH:19]=1>>[S:1]1[C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][N:8]2[C:30]([C:25]2[C:24]([C:21]3[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=3)=[CH:28][N:27]([CH3:29])[N:26]=2)=[O:31])=[CH:4][C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2

Participants

3

Reactant 2

HCID 197686484-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acidHCID 23146368HCID 23146368, compound

Product 1

HCID 23146244HCID 23146244, compoundYield 2.4%

Procedure

The title compound (6 mg) was prepared from 2-benzo[b]thiophen-2-ylmethyl-piperidine D83(133 mg) and 4-(4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (140 mg) according to a procedure similar to that described for Example 4.

Sources & evidence

ORD record
ord-3f1a5f732b3e46af85e6a4638569f34e
Source dataset
uspto-grants-2008_12
Patent number
US07470710B2

Reaction notes

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