Sodium Thiosulfate → HCID 86613308, compound

Participants

Reaction Steps

To a mixture consisting of (1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-phenyl-isoxazol-5-yl}-cyclopropyl)-methanol (Example 1, Compound E, 4.0 g) in dichloromethane (60 mL) is added 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one (7.0 g.) The mixture is stirred overnight at room temperature. The mixture is treated with aqueous sodium thiosulfate (20 mL) and the layers are thoroughly mixed and separated. The organic layer is washed sequentially with water and brine solution and is dried over anhydrous sodium sulfate. The mixture is filtered and the filtrate is concentrated under reduced pressure to afford the solid common synthetic intermediate (4.1 g.)

Provenance & Evidence