Methyl 1-methylcyclopropane-1-carboxylate → HCID 68962802, compound

HRID 2378056Notes

Reaction equation

HRID 2378056 reaction equation
[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[N:21][OH:22])[CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].C[O:26][C:27]([C:29]1([CH3:32])[CH2:31][CH2:30]1)=O>>[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:27]([C:29]3([CH3:32])[CH2:31][CH2:30]3)([OH:26])[O:22][N:21]=2)=[CH:9][CH:8]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 543995Methyl 1-methylcyclopropane-1-carboxylateHCID 72579577HCID 72579577, compound

Product 1

HCID 68962802HCID 68962802, compound

Procedure

The synthetic intermediate 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-(1-methyl-cyclopropyl)-4-phenyl -4,5-dihydro-isoxazol-5-ol (0.833 g) is prepared from Example 1, Compound B and 1-methyl-cyclopropanecarboxylic acid methyl ester by the general method described in Step A of Example 35.

Sources & evidence

ORD record
ord-04df5a8196ec434bad25572970d9b00e
Source dataset
uspto-grants-2008_12
Patent number
US07470715B2

Reaction notes

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