Potassium Cyanide → HCID 68958470, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture consisting of methanesulfonic acid 1-[3-(4-methoxymethoxy-phenyl)-4-phenyl-isoxazol-5-yl]-cyclopropylmethyl ester (synthetic intermediate prepared in Example 11, Step iv, 0.45 g) in N,N-dimethylformamide (4 mL) is added potassium cyanide (0.17 g.) The mixture is stirred at 80° C. for five hours and is subsequently diluted with ethyl acetate (30 mL.) The mixture is sequentially washed with water (15 mL) and brine solution (15 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford the synthetic intermediate {1-[3-(4-methoxymethoxy-phenyl)-4-phenyl-isoxazol-5-yl]-cyclopropyl}-acetonitrile (0.38 g.)

Provenance & Evidence