反应详情

温度

110 °C

To a solution of (2S,6S)-2-(4-cyclohexyl-phenoxymethyl)-6-methyl-2,3,5,6-tetrahydro-oxazolo[3,2-a]pyrimidin-7-one (38 mg, 0.111 mmol) in toluene (3 ml) was added 96 mg (1.11 mmol) of manganese(IV) oxide. The reaction mixture was heated at 110° C. overnight. The reaction mixture was filtered and the filtrate concentrated and loaded onto a silica gel column, and eluted with 2-7% isopropanol/methylene chloride to afford 8 mg of (S)-2-(4-cyclohexyl-phenoxymethyl)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate concentrated
3. washeluted with 2-7% isopropanol/methylene chloride