HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 2-Amino-6-methylpyridine | HCID 15765 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | 106.4% |
Reaction Steps
Add diethyl ethoxymethylenemalonate (10.0 ml, 55.0 mmol) to a solution of 6-methyl-pyridin-2-ylamine (5.41 g, 50.0 mmol) in toluene (100 ml). Heat the mixture under reflux overnight. Evaporate the solvent in vacuo to provide 2-[(6-methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester (14.8 g) as a white solid. MS (ES+): 279 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470705B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-72c4d722c478427eb8c94cc1e20851bb |
| Source note | uspto-grants-2008_12 |