Sodium Carbonate → HCID 86613790, compound

Participants

Reaction Steps

Heat at 80° C. a solution of (+/−)-cis-4-acetylamino-2-ethyl-6-methoxy-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid isopropyl ester (100 mg, 0.298 mmol) in 5 N HCl (1 mL) for 4 h. Cool the reaction mixture to room temperature, pour the crude onto a saturated solution of sodium carbonate and extract with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and remove the solvent under reduced pressure, to afford the title compound (85 mg, 98%). MS (ES+): 277 (M−NH2).

Provenance & Evidence