Trifluoroacetic acid → HCID 11513092, compound

Participants

Reaction Steps

Add trifluoroacetic acid (1 mL) to a solution of (+/−)-cis-4-[(3,5-bis-trifluoromethyl-benzyl)-[2-(2-tert-butoxycarbonylamino-ethyl)-2H-tetrazol-5-yl)-amino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid isopropyl ester (61 mg, 0.079 mmol) in dichloromethane (3 mL) and stir the mixture at room temperature for 3 h. Pour the reaction mixture onto a saturated solution of sodium bicarbonate and extract with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and remove the solvent under reduced pressure. Purify the residue by silica gel chromatography, eluting with ethyl acetate, to afford the title compound (24 mg, 45%). MS (ES+): 669 (M+H).

Provenance & Evidence