Hydrochloric Acid → HCID 11563853, compound

Participants

Reaction Steps

Add LiOH 2.5 M (1.9 mL, 4.8 mmol) to a solution of (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid 2-methoxycarbonyl-2-methyl-propyl ester (74 mg, 0.10 mmol) in THF (1.9 mL). Stir the mixture at room temperature for 72 h. Acidify with 1 M HCl. Extract the aqueous phase with dichloromethane. Dry the organic layers over Na2SO4, filter, and concentrate. Purify the residue using silica gel chromatography (elution with hexane/ethyl acetate) to afford the title compound (14 mg, 20%). MS (ES+): 698 (M+H).

Provenance & Evidence