Pyridine → HCID 86760803, compound

Participants

Reaction Steps

Add isopropyl chloroformate (8.50 mL, 8.50 mmol) to a solution of (+/−)-cis-N-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1,5]naphthyridin-4-yl)acetamide (0.404 g, 1.702 mmol), pyridine (1.370 mL, 17.02 mmol) in dichloromethane (10 mL) at 0° C. and slowly warm to room temperature. After 12 h, remove the solvent under reduced pressure. Purify the crude material using silica gel chromatography, eluting with ethyl acetate (neat), to afford the title compound (0.496 g, 91%). MS (ES+): 322 (M+H).

Provenance & Evidence