Sodium Carbonate → HCID 86613808, compound

Participants

Reaction Steps

Heat at 80° C. a solution of (+/−)-cis-4-acetylamino-6-methoxy-2-methyl -3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid isopropyl ester (405 mg, 1.261 mmol) in 5 N HCl (3 mL) for 3 h. Cool the reaction mixture to room temperature, pour into a saturated solution of sodium carbonate, and extract with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and remove the solvent under reduced pressure, to afford the title compound (0.315 g, 89%). MS (ES+): 280 (M+H).

Provenance & Evidence