3-Fluoro-5-(trifluoromethyl)benzoyl chloride → HCID 86613811, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedure described for the synthesis of Example 47, using (+/−)-cis-4-(3,5-bis-trifluoromethyl-benzylamino)-6-methoxy-2-methyl-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid isopropyl ester (0.210 g, 0.415 mmol), 3-fluoro-5-trifluoromethyl benzoyl chloride (0.095 mL, 0.631 mmol) and pyridine (0.10 mL). Purify using silica gel column chromatography (gradient eluent, 0-30% ethyl acetate in hexane) to provide the title compound (0.246 g, 88%). MS (ES+): 696 (M+H).

Provenance & Evidence