3,5-Bis(trifluoromethyl)benzyl bromide → HCID 86613812, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedure described in Example 49, Step 2, by replacing (+/−)-N-(1-cyclopently-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1,5]napthyridin-4-yl)-acetamide with cis-4-acetylamino-2-methyl-6-trifluoromethyl-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid isopropyl ester (0.065 g, 0.018 mmol), and using 3,5-bis trifluoromethyl benzylbromide and lithium hexamethyldisilazide. Purify using silica gel column chromatography (gradient eluent, neat ethyl acetate) to afford the title compound (0.031 g, 30%). MS (ES+): 586 (M+H).

Provenance & Evidence