Isopropyl chloroformate → HCID 58926753, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedure described in Example 46, Step 2, by replacing (+/−)-cis-N-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1,5]naphthyridin-4-yl)acetamide, with (2-ethyl-3-methyl-1,2,3,4,6,7,8,9-octahydro benzo [b][1,5]napthyridin-4yl)-(5,6,7,8-tetrahydro-quinolin-3-yl)-amine (0.575 g, 1.52 mmol), and using isopropyl chloroformate, pyridine, and dimethylaminopyridine. Purify using silica gel column chromatography (gradient eluent, neat ethyl acetate) to provide the title compound (0.218 g, 31%). MS (ES+): 463 (M+H).

Provenance & Evidence