3,5-Bis(trifluoromethyl)benzyl bromide → HCID 86613817, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedure described in Example 49, Step 2, by replacing (+/−)-N-(1-cyclopentyl-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1,5]napthyridin-4-yl)-acetamide, with 2-ethyl-3-methyl-4-(5,6,7,8-tetrahydro-quinolin-3-ylamino)-3,4,6,7,8,9-hexahydro-2H-benzo[b][1,5]napthyridine-1-carboxylic acid isopropyl ester (0.175 g, 0.378 mmol), and using 3,5-bis trifluoromethyl benzyl bromide and lithium hexamethyldisilazide. Purify using silica gel column chromatography (gradient eluent, 50:50 ethyl acetate in hexane) to afford the title compound (0.052 g, 20%). MS (ES+): 689 (M+H).

Provenance & Evidence