HCID 21583954, compound → Methyl Salicylate

HRID 2378140Notes

Reaction equation

HRID 2378140 reaction equation
C(O)C.O.[C:5]([O:14][CH3:15])(=[O:13])[C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8].[NH2+]1CCN=C1>CCOCC>[C:5]([O:14][CH3:15])(=[O:13])[C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8]

Participants

4

Reactant 2

HCID 21583954HCID 21583954, compoundHCID 86598827HCID 86598827, compound

Product 1

HCID 4133Methyl Salicylate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
70 °C

Procedure

740 Grams of a mixed solvent of ethanol/water/methyl salicylate=60/30/10 was added to 100 g of a polymer solution (polymer concentration: about 42%) substituted with imidazolinium cations obtained as in Example 4, to dissolve the polymer, to obtain a solution having the polymer concentration of 5%. To 100 g of this mixed solution was added 0.5 g of the aforementioned polyglycerolpolyglycidyl ether (described-above) used in Example 4, this was placed into a 100 ml sample bottle, the sample bottle was sealed, the bottle was heated for 1 hour in a constant temperature bath at 70° C. to gelate the material, to obtain the integrated gelated-type patch material (RC1) of the present invention with methyl salicylate-based percutaneous absorption drug absorbed therein.

Workup

  1. customobtained as in Example 4
  2. dissolutionto dissolve the polymer
  3. customto obtain a solution
  4. customthe sample bottle was sealed

Sources & evidence

ORD record
ord-60ee426752024b22b2a553937be5f4dd
Source dataset
uspto-grants-2008_12
Patent number
US07470738B2

Reaction notes

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