反应详情

A mixture of (3,5-dimethoxy-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanol from above and activated MnO2 (10 g, 115 mmol) in methylene chloride (60 mL) was stirred at room temperature for 18 h. More MnO2 (7 g) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3,5-dimethoxy-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone as an off-white solid (3.13 g, 56% yield 2 steps). The sample was used in the next step without further purification.

1. waitkept for overnight
2. filtrationThe suspension was filtered
3. customRemoval of solvent