HCID 69205838, compound → HCID 69204178, compound

HRID 2378275Notes

Reaction equation

HRID 2378275 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)[OH:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)=[O:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

Participants

4

Reactant 1

HCID 69205838HCID 69205838, compound

Product 1

HCID 69204178HCID 69204178, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalyst2×HCID 6344DichloromethaneSolvent

Procedure

A mixture of (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl) -methanol from above and activated MnO2 (2.6 g, 30 mmol) in methylene chloride (30 if L) was stirred at room temperature for 18 h. More MnO2 (2 g) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone as a brown oil (1.58 g, 85% crude yield 2 steps). The sample was used in the next step without further purification.

Workup

  1. waitkept for overnight
  2. filtrationThe suspension was filtered
  3. customRemoval of solvent

Sources & evidence

ORD record
ord-67d17ecd437d444ea959d2de81fb4211
Source dataset
uspto-grants-2008_12
Patent number
US07470723B2

Reaction notes

Loading…