(3-Ethoxy-4-methoxy-phenyl)-(4-methoxy-3-methyl-phenyl)-methanol → HCID 69205620, compound

Participants

Reaction Steps

A mixture of (3-ethoxy-4-methoxy-phenyl)-(4-methoxy-3-methyl-phenyl) -methanol from above and activated MnO2 (3 g, 35 mmol) in methylene chloride (30 mL) was stirred at room temperature for 18 h. More MnO2 (1.3 g×2) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3-ethoxy-4-methoxy-phenyl)-(4-methoxy-3-methyl-phenyl)-methanone as a white solid (1.23 g, 68% crude yield 2 steps). The sample was used in the next step without further purification.

Provenance & Evidence