Ethyl 2-ethyl-3-oxopentanoate → HCID 25073000, compound

HRID 237828Notes

Reaction equation

HRID 237828 reaction equation
[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@H:13]3[O:17][C:16]([NH2:18])=[N:15][CH2:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O:23][C:24](=O)[CH:25]([CH2:30][CH3:31])[C:26](=O)[CH2:27][CH3:28])C>C(Cl)(Cl)Cl>[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][CH:13]3[O:17][C:16]4=[N:18][C:24](=[O:23])[C:25]([CH2:30][CH3:31])=[C:26]([CH2:27][CH3:28])[N:15]4[CH2:14]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14203251Ethyl 2-ethyl-3-oxopentanoateHCID 66875140(S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

Product 1

HCID 25073000HCID 25073000, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 2-ethyl-3-oxo-pentanoic acid ethyl ester in accordance with the procedures of O.-S. Adetchessi, et. al., Tetrahedron, 61, (2005), 4453-4460. [α]D25 −11.20 (c 0.5, CHCl3).

Sources & evidence

ORD record
ord-9e95bb13e11347a8a42bfe400a877d80
Source dataset
uspto-grants-2014_02
Patent number
US08642603B2

Reaction notes

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