HCID 61087120, compound → HCID 24261598, compound

Participants

Reaction Steps

To a stirred solution of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(3-methoxy-phenyl)-methanol (2.08 g crude, 6.7 mmol) in CH2Cl2 (15 mL) at room temperature was added activated MnO2 powder (3.6 g, 41.4 mmol) and kept adding 23 equivalents of MnO2 every 35 h until HPLC showed disappearance of the starting material. The black suspension was filtered through a Celite pad, concentrated in vacuo to give (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(3-methoxy-phenyl)-methanone as an oil (2.0 g, 109% crude yield): 1H NMR (CDCl3) δ 3.86 (s, 3H, OCH3), 4.26-4.36 (m, 4H, CH2CH2), 6.84-7.42 (m, 7H, Ar). The product was used in the next step without further purification.

Provenance & Evidence