HCID 63895443, compound → HCID 24820456, compound

Participants

Reaction Steps

To a stirred solution of benzo[1,3]dioxol-5-yl-(3-methoxy-phenyl) -methanol (2.23 g crude, 7.6 mmol) in CH2Cl2 (20 mL) at room temperature was added activated MnO2 powder (3.5 g, 40 mmol) and kept adding 23 equivalents of MnO2 every 35 h until HPLC showed disappearance of the starting material. The black suspension was filtered through a Celite pad, concentrated in vacuo to give benzo[1,3]dioxol-5-yl-(3-methoxy-phenyl)-methanone as an oil (1.78 g, 89% crude yield). The product was used in the next step without further purification.

Provenance & Evidence