HCID 59858004, compound → 1,1-Dimethylethyl N-[6-[(4-hydroxy-3-pyrrolidinyl)methyl]-2-pyridinyl]carbamate

Participants

Reaction Steps

A suspension of [6-(1-benzyl-4-hydroxy-pyrrolidin-3-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester I-3 (0.002 mol) and 10% Pd—C (0.7 g) in MeOH (30 mL) was stirred at 45° C. under hydrogen overnight. Then, the catalyst was removed by filtration and washed with MeOH (30 mL). The filtrate was concentrated to give II-1. Most of the product was used in the next reaction without further purification (100%). Some was purified by column chromatography (silica gel, CH2Cl2:MeOH:Et3N, 6:30:0.1) to determine NMR and mass spectrum.

Provenance & Evidence