HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-methoxybut-2-ynoate → (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-methoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-methoxybut-2-ynoate | HCID 23249615 | — |
| Reactant | (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 66875140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-methoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 25071734 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 4-methoxy-but-2-ynoic acid ethyl ester (Larock, J Org Chem 2002, 67, 9318) employing the procedure described in Example 105. [α]D25 −17.80 (c 0.5, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-53ab9607b5c940769ebcf82b5d28847a |
| Source note | uspto-grants-2014_02 |