Ethyl vinyl ether → HCID 68822771, compound

Participants

Reaction Steps

A mixture of 2 g (7.9 mmol) of (16) and 0.84 ml (8.7 mmol) ethyl vinyl ether in 2 ml THF was stirred at room temperature in the presence of 20 μl (0.32 mmol) trifluoroacetic acid for 2 days. After a short column filtration (SiO2) using diethyl ether as eluent and evaporation of the solvent 2.6 g of the crude product (18) was obtained. Flash chromatography, using SiO2 and cyclohexanelEtOAc=95:5 as eluent, afforded 2.10 g (82%) of (18) as a ˜1:1 mixture of diastereomers.

Provenance & Evidence